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This high-volatility slot game comes with a Pay Anywhere feature which rewards players with winnings when they hit eight or more identical symbols anywhere on the reels. It also has an extremely lucrative Free Spins feature with multipliers that can be as high as 500x bet. A pragmatic study that involves a variety investigators and includes participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This type of heterogeneity which is essential for a pragmatic trial to be reliable and reduce bias in results, is also necessary. However too much heterogeneity could lead to issues with the design of the trial. Pragmatic Play, one of the major players in the live casino market, provides an array of traditional table games, including Blackjack and Roulette. The live studios of Pragmatic Play in Romania and Malta provide customers with an authentic gambling experience, as well a full range of virtual betting options. 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Legality Pragmatic Play is renowned for its top-quality games and also for providing an outstanding user experience. Its software is designed to work on mobile devices and supports different languages. Despite its relatively young age it has already established itself as a premier casino gaming platform. Wolves is one of the most recent releases that is a 5-reel slot machine that has a high RTP and stunning graphics. Other notable titles include Wolf Gold and Chilli Heat. Pragmatic trials are designed to replicate real-world situations and have the highest external validity. They are typically requested by practitioners and policymakers to guide their decisions. They can be used to determine the cause-effect relationship of an intervention with its outcomes. However, they should not be used to substitute for the use of explanation studies. The pragmatism concept is controversial, and there are questions about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 made an distinction between explanation-based studies, which support the physiological hypothesis or clinical hypothesis, and pragmatic trials, which inform the practice and policy decision-making. They also suggested a framework known as PRECIS for pragmatic trials.2 This tool attempted to define the traits of a pragmatic research study which includes recruitment, design, implementation of the intervention, and follow-up. The number of pragmatic trials is increasing. A recent Medline search using the keywords pragmatic and naturalistic, restricted to controlled trials randomized to control (RCTs), yielded 34 articles, which are shown in red in Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatism. It is important to remember that the majority of these studies were conducted in primary care settings.